Solution consist of following projects:
<cc1:ExpressionASPxGridView>
    <Columns>
        ....                    
    </Columns>
    <TotalSummary>
        <cc1:ExpressionSummary FieldName="Column1" ShowInColumn="Column1" Expression="AVG(Column4/Column3)+SUM(Column3)"/>
        ...
    </TotalSummary>
</cc1:ExpressionASPxGridView>
xrLabel.SetExpression("AVG(Column4/Column3)+SUM(Column3)");